Research Library
The primary sources
Our explainers translate research into plain language. This page is the opposite direction: the original, published journal articles themselves, for clinicians, researchers, or anyone who wants to go straight to the source. See how we grade evidence for what the labels below mean.
- Shown in animal modelsRead the article
Development of Shoulder Osteoarthritis and Bone Lesions in Female and Male Rats Subjected to a High Fat/Sucrose Diet
Abughazaleh N, Smith H, Seerattan RA, Hart DA, Reimer RA, Herzog W. Scientific Reports. 2024. doi:10.1038/s41598-024-76703-4
A rat study describing how a high-fat, high-sucrose diet contributed to shoulder osteoarthritis and bone changes, in both female and male animals.
- Read the article
Reflections on Obesity, Exercise, and Musculoskeletal Health
Herzog W. Journal of Sport and Health Science. 2020. doi:10.1016/j.jshs.2019.11.004
A perspective piece connecting obesity, physical activity, and musculoskeletal health.
- Shown in animal modelsRead the article
Protective Effect of Prebiotic and Exercise Intervention on Knee Health in a Rat Model of Diet-Induced Obesity
Rios JL, Bomhof MR, Reimer RA, Hart DA, Collins KH, Herzog W. Scientific Reports. 2019. doi:10.1038/s41598-019-40601-x
A rat study testing whether a prebiotic fiber plus exercise could protect knee joint health in the context of diet-induced obesity.
- Established in humansRead the article
Prebiotics Reduce Body Fat and Alter Intestinal Microbiota in Children Who Are Overweight or With Obesity
Nicolucci AC, Hume MP, Martínez I, Mayengbam S, Walter J, Reimer RA. Gastroenterology. 2017. doi:10.1053/j.gastro.2017.05.055
A human study in children with overweight or obesity finding that a prebiotic fiber supplement reduced body fat and changed gut bacteria.
- Shown in animal modelsRead the article
A High-Fat High-Sucrose Diet Rapidly Alters Muscle Integrity, Inflammation and Gut Microbiota in Male Rats
Collins KH, Paul HA, Hart DA, et al. Scientific Reports. 2016. doi:10.1038/srep37278
A rat study showing how a high-fat, high-sucrose diet quickly affected muscle tissue, inflammation, and gut bacteria.
- Shown in animal modelsRead the article
Interactive Effects of Oligofructose and Obesity Predisposition on Gut Hormones and Microbiota in Diet-Induced Obese Rats
Cluny NL, Eller LK, Keenan CM, Reimer RA, Sharkey KA. Obesity. 2015. doi:10.1002/oby.21017
A rat study on how a prebiotic fiber interacts with pre-existing obesity risk to affect gut hormones and gut bacteria.
- Shown in animal modelsRead the article
Relationship Between Inflammation, the Gut Microbiota, and Metabolic Osteoarthritis Development: Studies in a Rat Model
Collins KH, Paul HA, Reimer RA, Seerattan RA, Hart DA, Herzog W. Osteoarthritis and Cartilage. 2015. doi:10.1016/j.joca.2015.03.014
A rat study exploring how inflammation and gut bacteria relate to the development of metabolic osteoarthritis.
- Shown in animal modelsRead the article
Using Diet-Induced Obesity to Understand a Metabolic Subtype of Osteoarthritis in Rats
Collins KH, Reimer RA, Seerattan RA, Leonard TR, Herzog W. Osteoarthritis and Cartilage. 2015. doi:10.1016/j.joca.2015.01.015
A rat study proposing a distinct, metabolically-driven subtype of osteoarthritis linked to diet-induced obesity.
- Established in humansRead the article
Weight Loss During Oligofructose Supplementation Is Associated With Decreased Ghrelin and Increased Peptide YY in Overweight and Obese Adults
Parnell JA, Reimer RA. American Journal of Clinical Nutrition. 2009. doi:10.3945/ajcn.2009.27465
A human study in adults with overweight or obesity finding that weight loss during a prebiotic fiber supplement was linked with changes in appetite-related hormones.
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